Multiple people were injured Tuesday after a UPS cargo plane crashed near Louisville Muhammad Ali International Airport (SDF) in Kentucky.

UPS Flight 2976 crashed at about 5:15 p.m. local time after departing from SDF, according to the Federal Aviation Administration (FAA).

The McDonnell Douglas MD-11 was headed to Daniel K. Inouye International Airport in Honolulu, FAA officials said.

The Louisville Metro Police Department confirmed its officers, along with multiple other agencies, were responding to the crash, which happened near the UPS Worldport.

Police said multiple people were injured. It is unclear if there were any fatalities.

“This is an active scene with fire and debris,” police wrote in an X post. “Stay away.”

The agency later issued an emergency shelter-in-place alert for all locations within five miles of the airport.

SDF noted its airfield is closed.

The FAA and National Transportation Safety Board (NTSB) will investigate, with the NTSB taking the lead.

“Kentucky, we are aware of a reported plane crash near Louisville International Airport,” Kentucky Gov. Andy Beshear wrote in a statement on social media. “First responders are onsite, and we will share more information as available. Please pray for the pilots, crew and everyone affected. We will share more soon.”

Anna McMullen, who lives seven minutes from the Louisville airport told Fox News Digital her husband called her and thought “something was burning” downtown.

“All you could see in the sky around the airport was black smoke in billows,” McMullen said. “I heard explosions and they are still going off which mean the plane could have hit the petroleum supply tanks.”

She added that the normal pattern for the UPS planes is to be loaded before they take off.

“We have lived here 25 years and never seen a UPS plane crash,” McMullen said. “The sun has set but the smoke is still horrible. We can still hear the explosions.”

UPS and Ford did not immediately respond to inquiries from FOX Business.

Multiple people were injured Tuesday after a UPS cargo plane crashed near Louisville Muhammad Ali International Airport (SDF) in Kentucky.

UPS Flight 2976 crashed at about 5:15 p.m. local time after departing from SDF, according to the Federal Aviation Administration (FAA).

The McDonnell Douglas MD-11 was headed to Daniel K. Inouye International Airport in Honolulu, FAA officials said.

The Louisville Metro Police Department confirmed its officers, along with multiple other agencies, were responding to the crash, which happened near the UPS Worldport.

Police said multiple people were injured. It is unclear if there were any fatalities.

“This is an active scene with fire and debris,” police wrote in an X post. “Stay away.”

The agency later issued an emergency shelter-in-place alert for all locations within five miles of the airport.

SDF noted its airfield is closed.

The FAA and National Transportation Safety Board (NTSB) will investigate, with the NTSB taking the lead.

“Kentucky, we are aware of a reported plane crash near Louisville International Airport,” Kentucky Gov. Andy Beshear wrote in a statement on social media. “First responders are onsite, and we will share more information as available. Please pray for the pilots, crew and everyone affected. We will share more soon.”

Anna McMullen, who lives seven minutes from the Louisville airport told Fox News Digital her husband called her and thought “something was burning” downtown.

“All you could see in the sky around the airport was black smoke in billows,” McMullen said. “I heard explosions and they are still going off which mean the plane could have hit the petroleum supply tanks.”

She added that the normal pattern for the UPS planes is to be loaded before they take off.

“We have lived here 25 years and never seen a UPS plane crash,” McMullen said. “The sun has set but the smoke is still horrible. We can still hear the explosions.”

UPS and Ford did not immediately respond to inquiries from FOX Business.